NIH funded postdoctoral position is immediately available for highly motivated individuals seeking to build a career in lung diseases. The lab is interested in basic mechanistic and translational research focusing on bzip transcription factor, Nrf2. Previous work from the lab have demonstrated that this transcription factor determines the susceptibility and severity of emphysema, asthma and various pulmonary diseases by regulating environmental stress response.
Postdoctoral Position in lung disease
The project involves the molecular mechanism of Nrf2 dependent regulation of stress response in mice disease models as well as translational aspect of targeting this transcription factor intervening diseases. Individuals with a strong background in molecular biology/biochemistry are encouraged to apply. The position is restricted to US citizens/permanent residents due to NIH training grant restriction. The candidate should have a PhD in Molecular biology/Cancer biology/biochemistry or related discipline.
Postdoctoral Position in radiation/stem cell biology
Primary focus of this project is to understand and develop Nrf2 based therapeutics to treat radiation induced bystander effect (oxidative and inflammatory damage to normal tissues) caused during radiotherapy or accidental exposure. Another arm of the project is to develop stem cell based therapies to treat lung inflammatory diseases caused by radiation and other environmental toxicants. The candidate should have a PhD and strong background in Molecular biology/immunology/Cancer biology/biochemistry or related discipline. Expertise in radiation biology/ stem cell biology with animal research is highly desirable.
Postdoctoral position in Cancer Biology
NIH funded postdoctoral position is immediately available for highly motivated individuals seeking to build a career in cancer biology. The lab is interested in basic, mechanistic and translational research focusing on bzip transcription factor, Nrf2 that regulates several drug and electrophile detoxification genes. Previous work from our lab has shown that gain of Nrf2 activity in lung tumor cells confers chemo and radioresistance due to mutation in its inhibitor, Keap1. Primary focus of this project is to understand the novel pathways regulated by Nrf2 in cancer cells which confer resistance to chemotherapy, radiotherapy and promote tumor growth. Another focus of the project is to develop siRNA and small molecule based drugs/ strategies for targeting Nrf2 to treat lung and other drug resistant cancers. Candidates with PhD and strong background in Cancer biology with mice xenograft model can contact by email.
Send CV with names of 3 references to Shyam Biswal, School of Public Health, Johns Hopkins University, by email Biswallab@gmail.com