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Friday, August 1, 2008

Scientist (Invitrogen)

Invitrogen Corporation
Frederick, Maryland


Description: GIBCO/Invitrogen, a leader of cell culture reagent development, is committed to the promising developments in Stem Cells and Regenerative Medicine and is devoted to developing innovative products supporting stem cell research, tissue engineering and cell therapy based applications. As a member of the stem cell team, the successful applicant will be developing novel stem cell culture media, using innovative platform based technologies to support product development. To develop innovative stem cell culture media, the candidate should be capable of applying molecular, cellular and image based techniques for characterizing stem cell types with gene-expression profiling, immunocytochemistry and quantitative cell culture based functional bio-assays.

The Scientist will perform different types of stem cell cultures, carry out laboratory assays associated with the research and development of new media formulation, perform cell characterization using cell and molecular biology techniques, PCR, immunocytochemistry and quantitative cell culture assays.

Education Requirements:
MS or PhD in Cell Biology, Biochemistry, Molecular Biology, or related discipline. Extensive experience in stem cell culture will be given consideration as an alternative to an advanced degree.

Experience Requirements:
• Experience (2-3 years) in stem cell biology, cell cultures, cell based assays, PCR techniques.
• Product development experience (2-3 years) in cell culture / biotech / pharma.
• Ability to work in a team or/and independent work skills in a fast-paced environment.
• Provide technical support to QC and manufacturing.

Expected Behavior and Functions to perform:
• Develop new stem cell culture products, new media and cell based assays.
• Lead projects and interact with different product development teams.
• Communication abilities to perform scientific documentation and presentation.

Willingness to travel when needed (5%).

Postdoctoral Fellow - Oncology

MedImmune, LLC
Gaithersburg, Maryland

MedImmune is a recognized leader in the biotechnology industry, we use the latest advances in science, technology and medicine to develop innovative products that improve the quality of human health. We strive to create a work environment that is professionally and personally rewarding, characterized by respect, integrity and opportunities for growth. Hundreds of thousands of patients have benefited from our products, which are designed to treat or prevent infectious diseases, cancer and inflammatory diseases. Our extensive research and development efforts are focused on these same areas. Both individual contributions and team successes are critical on the path to scientific and medical breakthroughs.

MedImmune, the global biologics unit of AstraZeneca is seeking a highly motivated postdoctoral fellow to join the cancer/stem cell platform to lead an independent project aimed at the characterization of modulators of stem cell self-renewal signaling pathways. The candidate will utilize state-of-the art technologies to validate targets in these pathways for oncology therapeutic purposes, particularly their relevance as cancer stem cell and/or drug resistance therapeutics. He/She will also be involved in the identification of new players in these pathways using various approaches including genomics, proteomics, and chemical biology.

Requirements .
Prior experience with developmental pathway signaling and familiarity with primary tissue handling, FACS analysis and in vivo cancer models is highly desirable. Candidates must have excellent communication skills and publication records, and must be able to work in a highly collaborative environment. Candidates must have advanced at least one research project as evidenced by a first author paper published or accepted for publication. The position offers a unique opportunity for a talented scientist to work in a dynamic and innovative environment and to develop their career at the interface of basic research and drug discovery.

A recent Ph.D. in Molecular/Cell Biology as well as experience with molecular/cell biology techniques is required. Preference will be given to recent graduates but candidates with less than 2 years of postdoc experience will be considered.

If you are interested in this position, apply online at www.medimmune.appone.com and search for Req 00866.

MedImmune, LLC. is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, gender, age, national origin, disability, veteran status, or any other characteristic protected by federal, state or local law.

Associate Professor

The Georgetown University Department of Human Science is seeking for the fall 2008 semester a fulltime tenure track associate professor with concurrent assistant department chair responsibilities to join its dynamic faculty. The successful candidate will teach undergraduate courses in human genetics and genomics/informatics and assist in development of graduate programs. Our college level basic science curriculum emphasizes human health science with a focus on physiological adaptation and systems integration. Applicants must have a Ph.D., M.D. or equivalent and have a primary interest in teaching and scholarship and in investigator-initiated laboratory research with an emphasis in molecular biology, genetics, genomics and/or informatics. The successful candidate will have a teaching and research portfolio with transferable current external funding that complements our curriculum and fulltime teaching-research faculty http://snhs.georgetown.edu/HS/index.html. To apply send cover letter of less than two pages indicating why you are interested and your qualifications, together with accompanying curriculum vitae and complete bibliography to: Professor Charles H. Evans, Jr., M.D., Ph.D., Chair, Human Science Department, School of Nursing and Health Studies, Georgetown University, POB 1107, 3700 Reservoir Road, NW, Washington, DC 20057 or via email to: che3@georgetown.edu

Research Associate

Children's National Medical Center
Washington, DC


Responsible for generating and testing scientific hypothesis related to virology, immunology or infectious disease research. Performs complex laboratory experiments under the guidance of Dashuang Shi on the structural biology of NAGS proteins. Works on independent project-designs study, collects and analyzes data.

Ph.D in science or equivalent doctoral degree in a related field.

5-7 years of related experience and progressive laboratory experience in the area of Genetics.

Demonstrated experience in laboratory methods, including cloning, site-directed mutagenesis, sequencing, gel electrophoresis, PCR analysis, protein purification, protein crystallization, post-crystallization treatment, chemical protein modofocation and DNA purification. Published research articles desirable.

Regulatory Specialist

Technical Resources International
Bethesda, MD

Founded in 1979, Technical Resources International, Inc. (TRI) provides a unique range of support services in the areas of Communications, Health and Information Technology to both private industry and government agency clients. TRI is currently seeking a Regulatory Specialist to join our Bethesda, MD team.

This position will prepare scientific and regulatory documents (e.g. clinical protocols, investigator’s brochures, informed consent forms, annual reports, investigational new drug applications, regulatory correspondence, and clinical summary reports) on behalf of the Division of Acquired Immunodeficiency Syndrome (DAIDS) at NIAID, NIH and FDA. Must have the ability to prepare investigator/pharmaceutical company meeting minutes, analyze preclinical and clinical data, prepare reports, perform literature searches and extract information to support regulatory documents.

Requirements include a M.S. degree or equivalent with 5 or more years of relevant work experience or a Ph.D. with 1 or more years of relevant work experience in pharmacology, toxicology, biochemistry, molecular biology, immunology, or a related field; excellent oral, written, and interpersonal skills; ability to analyze medical research data and review experimental protocols; and working knowledge of word processing, spreadsheet, and database management programs.

Submit resume and salary requirements to: Attn: AR, TRI, 6500 Rock Spring Dr, Suite 650, Bethesda, MD 20817, or fax to (301) 897-7401, or click here to apply.

Technical Resources International is fully committed to Equal Employment Opportunity and to attracting, retaining, developing and promoting the most qualified employees without regard to their race, gender, color, religion, national origin, age, physical or mental disability, veteran status, or any other characteristic prohibited by state or local law.

Postdoctoral Position (Molecular Genetics / Tumorigenesis)

Molecular Genetics / Tumorigenesis
National Institutes of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Department of Health and Human Services

Dr. Sunita K. Agarwal

Two postdoctoral positions are available immediately in the Genetics and Endocrinology Section, Metabolic Diseases Branch, NIDDK, to study the molecular mechanisms of endocrine tumorigenesis. Ground-breaking studies of the MEN1 gene, which is associated with the multiple endocrine neoplasia type 1 syndrome, have been made in the Genetics and Endocrinology Section for the past several years (Science 1997 276:402-407; Nature Genetics 1997 16:375; Cell 1999 96:143; PNAS 2003 100:10770; Horm Metab Res 2005 37:369 (Review); Neoplasia 2007 9:101). Experimental approaches will include chromatin immunoprecipitation, DNA-protein interactions, gene expression profiling, protein profiling, immunohistochemistry, in-situ hybridization, one- and two-hybrid assays, and reporter assays.

Applicants should have a Ph.D. or M.D. degree obtained in the past 3 years, with experience and interest in molecular biology, epigenetics, and immunohistochemical approaches.

To apply, click on the button below, or send - CV, cover letter, a brief statement of experience and research interests, and the names and telephone numbers of 3 references to:

Sunita K. Agarwal, Ph.D.
National Institutes of Health
NIDDK, Metabolic Diseases Branch
Bldg. 10, Room 9C-103
Bethesda, MD 20892
Phone: 301 402 7834
Fax: 301 496 0200
Email: sunitaa@mail.nih.gov


Scientist/Senior Scientist

Becton Dickinson & Company (BD)
Baltimore, MD


Required to work within a team developing a molecular diagnostic assay for an infectious agent. Reporting to the Group Leader the successful candidate will be responsible for optimization of the assay chemistry and sample processing procedures.

  1. Proficient in a broad range of practical techniques in molecular biology, in particular cloning, primer/probe design, PCR, and real-time PCR amplification/detection with demonstrated skills in developing/adapting procedures to meet specific objectives and solve complex problems.
  2. Independent with proven ability to apply scientific principles to achieve project objectives, including the design and execution of experiments, and analysis and interpretation of data.
  3. Collect, record, report and present results to peers and supervisor/manager either orally or in writing.
  4. Understand and leverage published research in molecular diagnostics.
  5. Provide technical guidance to other scientists within R&D as well as provide support to other functional groups.
  1. Proficiency in a broad range of techniques in molecular biology including cloning, primer/probe design, PCR, and real-time PCR amplification/detection.
  2. A history of self-motivation and work in a team environment are required.
  3. Experience of processing clinical samples for the recovery of nucleic acids together with a strong background in microbiology, virology and/or clinical laboratory science is advantageous.
  4. Experience of working in a cGMP environment is desirable.
  5. Excellent verbal and written communication skills are necessary together with experience in handling infectious biological samples.

  1. Bachelor’s or Master’s Degree in Life Sciences with >=3 years of laboratory experience in molecular biology.

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